Publications 1999
Aguet Michel
Gerber, H.P., Hillan, K.J., Ryan, A.M., Kowalski, J., Keller, G.A., Rangell, L., Wright, B.D., Radtke, F., Aguet, M., and Ferrara, N. (1999). VEGF is required for growth and survival in neonatal mice. Development 126, 1149-1159. Full text

Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J., MacDonald, H.R., and Aguet, M. (1999). Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immun. 10, 547-558. Abstract
Beard Peter
Fournier, N., Raj, K., Saudan, P., Utzig, S., Sahli, R., Simanis, V., and Beard, P. (1999). Expression of human papillomavirus 16 E2 protein in Schizosaccharomyces pombe delays the initiation of mitosis. Oncogene 18, 4015-4021. Abstract
Beermann Friedrich
Beermann, F. (1999). The tyrosinase related protein-1 (Tyrp1) promoter in transgenic experiments: targeted expression to the retinal pigment epithelium. Cell. Mol. Biol. 45, 961-968. Abstract

Beermann, F., Hunziker, A., and Foletti, A. (1999). Transgenic mouse for tumors of melanocytes and retinal pigment epithelium [Review]. Pigment Cell Res. 12, 71-80. Abstract

Pradervand, S., Wang, Q., Burnier, M., Beermann, F., Horisberger, J.D., Hummler, E., and Rossier, B.C. (1999). A mouse model for Liddle's syndrome. J. Am. Soc. Nephrol. 10, 2527-2533. Full text

Pradervand, S., Barker, P.M., Wang, Q., Ernst, S.A., Beermann, F., Grubb, B.R., Burnier, M., Schmidt, A., Bindels, R.J.M., Gatzy, J.T., Rossier, B.C., and Hummler, E. (1999). Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel. Proc. Natl. Acad. Sci. U.S.A. 96, 1732-1737. Full text

Schmidt, A., Tief, K., Yavuzer, U., and Beermann, F. (1999). Ectopic expression of RET results in microphthalmia and tumors in the retinal pigment epithelium. Int. J. Cancer 80, 600-605.Simmen, T., Schmidt, A., Hunziker, W., and Beermann, F. (1999). The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a di-leucine and a tyrosine-based signal. J. Cell Sci. 112, 45-53. Full text
Bucher Philipp
Bucher, P. (1999). Regulatory elements and expression profiles. Curr. Opin. Struct. Biol. 9, 400-407. Abstract

Bucher, P. (1999). Gene feature identification. In Genetics databases, M.J.Bishop ed. (Academic Press).

Périer, R.C., Junier, T., Bonnard, C., and Bucher, P.(1999). The eukaryotic promoter database (EPD): recent developments. Nucleic Acids Res. 27, 307-309. Full text

Hofmann, K., Bucher, P., Falquet, L., and Bairoch, A. (1999). The PROSITE database, its status in 1999. Nucleic Acids Res. 27, 215-219. Full text

Iseli, C., Jongeneel, C.V., and Bucher, P. (1999). ESTScan: a program for detecting, evaluating and reconstructing potential coding regions in EST sequences. In ISMB '99 (Proceedings of the 7th International Conference on intelligent systems for molecular biology), Menlo Park ed. (AAAI Press), pp. 138-148. Abstract

Maryanski, J.L., Attuil, V., Bucher, P., and Walker, P.R. (1999). A quantitative, single-cell PCR analysis of an antigen-specific TCR repertoire selected during an in vivo CD8 response: direct evidence for a wide range of clone sizes with uniform tissue distribution. Mol. Immunol. 36, 745-753. Abstract
Gasser Susan
Blasco, M.A., Gasser, S.M., and Lingner, J. (1999). Telomeres and telomerase, Genes Dev. 13, 2353-2359.

Cockell, M., and Gasser, S.M. (1999). Nuclear compartments and gene regulation. Curr. Opin. Genet. Dev. 9, 199-205.

Cockell, M., and Gasser, S.M. (1999). The nucleolus: Nucleolar space for RENT. Curr. Biol. 9, R575-R576.

Duncker, B.P., Pasero, P., Braguglia, D., Heun, P., Weinreich, M., and Gasser, S.M. (1999). Cyclin B/Cdk1 stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. Mol. Cell Biol. 19, 1226 - 1241.

Gotta, M., Laroche, T., and Gasser, S.M. (1999). Analysis of nuclear organization in S. cerevisiae. In: Methods in Enzymology 304, P. Wassarman and A. Wolffe eds. (Academic Press), pp. 663 - 672.

Leroy, D., Alghisi, C.-A., Roberts, E., Filhol-Cochet, O., and Gasser, S.M. (1999). Mutations in the C-terminal domain of Topoisomerse II affect meiotic function and Interaction with casein kinase 2b subunit. Mol. Cell. Bioch. 191, 85 -95.

Martin, S.G., Laroche, T., Suka, N., Grunstein, M. and Gasser, S.M. (1999). Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97, 621-633.

Pasero, P., Duncker, B.P. and Gasser, S.M. (1999). In vitro DNA replication in yeast nuclear extracts. In: Methods 18, 368-376.

Pasero, P., Duncker, B.P., Schwob, E., and Gasser, S.M. (1999). A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation competent origins of replication. Genes Dev. 13, 2159 - 2176.

Soltermann, A., Ernst, A.I., Leroy, D., Stahel, R.A., and Gasser, S.M. (1999). The cytochrome b(5) tail anchors and stabilizes subdomains of human DNA topoisomerase IIa in the cytoplasm of retrovirally infected mammalian cells. Exp. Cell Res. 249, 308-219.

Vassetzky, N.S., Gaden, F., Brun, C., Gasser, S.M., and Gilson, E. (1999). Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences. Nucleic Acids Res. 27, 4687-4694.
Iggo Richard
Chappuis, P.O., Estreicher, A., Dieterich, B., Bonnefoi, H, Otter, M., Sappino, A.P., and Iggo, R.(1999) Prognostic significance of p53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay. Int. J. Cancer 84, 587-593. Abstract

Gagnebin, J., Brunori, M., Otter, M., Juillerat-Jeanneret, L., Monnier, P., and Iggo, R. (1999). A photosensitising adenovirus for photodynamic therapy. Gene Ther. 6, 1742-1750. Abstract

Saller, E., Tom, E., Brunori, M., Otter, M., Estreicher, A., Mack, D.H., and Iggo, R. (1999). Increased apoptosis induction by 121F mutant p53. EMBO J. 18, 4424-4437. Full text

Yuan, Z.Q., Wong, N., Foulkes, W.D., Alpert, L., Manganaro, F., Andreutti-Zaugg, C., Iggo, R., Anthony, K., Hsieh, E., Redston, M., Pinsky, L., Trifiro, M., Gordon, P. H., and Lasko, D. (1999). A missense mutation in both hMSH2 and APC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening [letter] J. Med. Genet. 36, 790-793. Abstract
Kühn Lukas C.
Bahram, S., Gilfillan, S., Kühn, L.C., Moret, R., Schulze, J., Lebeau, A., and Schümann, K. (1999). Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism. Proc. Natl. Acad. Sci. U.S.A. 96, 13312-13317. Full text

Kaldy, P., Menotti, E., Moret, R., and Kühn, L.C. (1999). Identification of RNA-binding surfaces in iron regulatory protein-1. EMBO J. 18, 6073-6083. Full text

Kohler, S.A., Menotti, E., and Kühn, L.C. (1999). Molecular cloning of mouse glycolate oxidase: High evolutionary conservation and presence of an IRE-like sequence in the mRNA. J. Biol. Chem. 274, 2401-2407. Full text

Kühn, L.C. (1999). Iron overload: molecular clues to its cause. Trends Biochem. Sci. 24, 164-166. Abstract

Pfeiffer, R., Rossier, G., Spindler, B., Meier, C., Kühn, L.C., and Verrey, F. (1999). Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 18, 49-57. Full text

Pfeiffer, R., Loffing, J., Rossier, G., Bauch, C., Meier, C., Eggermann, T., Loffing-Cueni, D., Kühn, L.C., and Verrey, F. (1999). Luminal heterodimeric amino acid transporter in cystinurea. Mol. Biol. Cell 10, 4135-4147. Full text

Rossier, G., Meier, C., Bauch, C., Summa, V., Sordat, B., Verrey, F., and Kühn, L.C. (1999). LAT2: A new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J. Biol. Chem. 274, 34948-34954. Full text

Schümann, K., Moret, R., Künzle, H., and Kühn, L.C. (1999). Iron regulatory protein as an endogenous sensor of iron in intestinal rat mucosa. Possible implications for the regulation of iron absorption. Eur. J. Biochem. 260, 362-372. Full text
Kraehenbuhl Jean-Pierre
Benyacoub, J., Hopkins, S., Potts, A., Kelly, S., Kraehenbühl, J.P., Curtiss, R., De Grandi, P., and Nardelli-Haefliger, D. (1999). The nature of the attenuation of Salmonella typhimurium strains expressing human papillomavirus type 16 virus-like particles determines the systemic and mucosal antibody responses in nasally immunized mice. Infect. Immun. 67, 3674-3679.

Berdoz, J., Tallichet Blanc, C., Reinhardt, M., Kraehenbühl, J.P., and Corthesy, B. (1999). In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells. Proc. Natl. Acad. Sci.U.S.A. 96, 3029-3034.

Corthésy, B., and Kraehenbühl, J.P. (1999). Antibody-mediated protection of mucosal surfaces. Curr. Top. Microbiol. Immunol. 236, 93-111.

Crottet, P., and Corthesy, B. (1999). Mapping the interaction between murine IgA and murine secretory component carrying epitope substitutions reveals a role of domains II and III in covalent binding to IgA. J. Biol. Chem. 274, 31456-31462.

Crottet, P., Cottet, S., and Corthesy, B. (1999). Expression, purification and biochemical characterization of recombinant murine secretory component: a novel tool in mucosal immunology. Biochem. J. 341, 299-306.

Crottet, P., Peitsch, M. C., Servis, C., and Corthesy, B. (1999). Covalent homodimers of murine secretory component induced by epitope substitution unravel the capacity of the polymeric Ig receptor to dimerize noncovalently in the absence of IgA ligand. J. Biol. Chem. 274, 31445-31455.

Debard, N., Sierro, F., and Kraehenbühl, J.P. (1999). Development of Peyer's patches, follicle-associated epithelium and M cell: Lessons from immunodeficient and knockout mice [Review]. Semin. Immunol. 11, 183-191.

Marguerat, S., MacDonald, H.R., Kraehenbuhl, J.P., and van Meerwijk, J.P. (1999). Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin. J. Immunol. 163, 4033-4040.

Neutra, M.R., and Kraehenbuhl, J.P. (1999). Cellular and molecular basis for antigen transport across epithelial barriers. In Handbook of mucosal immunology, P. L. Ogra [et al.] eds. (New York: Academic Press), pp. 101-114.

Sirard, J.C., Niedergang, F., and Kraehenbuhl, J.P. (1999). Live attenuated Salmonella: a paradigm of mucosal vaccines. Immunol. Rev. 171, 5-26.

Velin, D., Fotopoulos, G., Kraehenbühl, J.P., and Acha-Orbea, H. (1999). Systemic antibodies can inhibit mouse mammary tumor virus-driven superantigen response in mucose-associated lymphoid tissues. J. Virol. 73, 1729-1733.
Lingner Joachim
Blasco, M.A., Gasser, S.M., and Lingner, J. (1999). Telomeres and telomerase, Genes Dev. 13, 2353-2359. Full text

Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., and Dalla-Favera, R. (1999). Direct activation of TERT transcription by c-MYC. Nature Genet. 21, 220-224. Abstract
Mach Jean-Pierre
Escobar, P., Yu, Z., Terskikh, A., Holmes, N., Corradin, G., Mach, J. P., and Healy, F. (1999). Induction in transgenic mice of HLA-A2.1-restricted cytotoxic T cells specific for a peptide sequence from a mutated p21ras protein. Clin. Exp. Immunol. 116, 214-219.

Houimel, M., Mach, J.P., Corthesy-Theulaz, I., Corthesy, B., and Fisch, I. (1999). New inhibitors of Helicobacter pylori urease holoenzyme selected from phage-displayed peptide libraries. Eur. J. Biochem. 262, 774-780.

Leconte, A., Garambois, V., Ychou, M., Robert, B., Pourquier, D., Terskikh, A., Mach, J. P., and Pelegrin, A. (1999). Involvement of circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model. Br. J. Cancer 80, 1373-1379.

Mach, J.P. (1999). Translational cancer research : definition, needs and means. Bull. Suisse Cancer 19, 211-213.

Robert, B., Dorvillius, M., Buchegger, F., Garambois, V., Mani, J. C., Pugnieres, M., Mach, J. P., and Pelegrin, A. (1999). Tumor targeting with newly designed biparatopic antibodies directed against two different epitopes of the carcinoembryonic antigen (CEA). Int. J. Cancer 81, 285-291.

Waibel, R., Alberto, R., Willuda, J., Finnern, R., Schibli, R., Stichelberger, A., Egli, A., Abram, U., Mach, J. P., Pluckthun, A., and Schubiger, P. A. (1999). Stable one-step technetium-99m labeling of his-tagged recombinant proteins with a novel Tc(I)-carbonyl complex. Nat. Biotechnol. 17, 897-901.
Mirkovitch Jovan
Fivaz, J., Bassi, M. C., Pinaud, S., Richman, L., Price, M., and Mirkovitch, J. (1999). EBV-derived episomes to probe chromatin structure and gene expression in human cells. In: Gene targeting protocols, E. Kmiec ed. (Totowa, NJ: Humana), pp. 167-182.
Peter Matthias
Bähler, J., and Peter, M. (1999). Cell polarity in yeast, D. G. Drubin, ed.OUP, in press.

Blondel, M., Alepuz, P.M., Huang, L.S., Shaham, S., Ammerer, G., and Peter, M. (1999). Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev. 13, 2284-2300.

Galan, J.M., and Peter, M. (1999). Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc. Natl. Acad. Sci. U.S.A. 96, 9124-9129.

Goode, B.L., Wong, J.J., Butty, A.-C., Peter, M., McCormack, A.L., Yates, J.R., Drubin, D.G., and Barnes, G. (1999). Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. J. Cell Biol. 144, 83-98.
Radtke Freddy
Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J., MacDonald, H. R., and Aguet, M. (1999). Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547-558. Abstract

Gerber, H. P., Hillan, K. J., Ryan, A. M., Kowalski, J., Keller, G. A., Rangell, L., Wright, B. D., Radtke, F., Aguet, M., and Ferrara, N. (1999). VEGF is required for growth and survival in neonatal mice. Development 126, 1149-1159. Abstract
Reichmann Ernst
Müller T., Choidas A., Reichmann E., and Ullrich, A. (1999). Phosphorylation and free pool of b-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration. J. Biol. Chem. 274, 10173-10183.

Peli, J., Schröter, M., Rudaz, C., Hahne, M., Meyer, C., Reichmann, E., and Tschopp, J. (1999). Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J. 18, 1824-1831.
Simanis Viesturs
Beltraminelli, N., Murone, M., and Simanis, V. (1999). The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited. J. Cell Sci. 112, 3103-3114. Full text

Cerutti, L., and Simanis, V. (1999). Asymmetry of the spindle pole bodies and spg1p GAP segregation during mitosis in fission yeast. J. Cell Sci. 112, 2313-2321. Full text

Fournier, N., Raj, K., Saudan, P., Utzig, S., Sahli, R., Simanis, V., and Beard, P. (1999). Expression of human papillomavirus 16 E2 protein in Schizosaccharomyces pombe delays the initiation of mitosis. Oncogene 18, 4015-4021. Abstract

Le Goff, X, Utzig, S., and Simanis, V. (1999). Controlling septation in fission yeast: finding the middle, and timing it right. Curr. Genet. 35, 571-584. Abstract

Le Goff, X., Woollard, A., and Simanis, V. (1999). Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe. Mol. Gen. Genet. 262, 163-172. Abstract
Sordat Bernard
Rossier, G., Meier, C., Bauch, C., Summa, V., Sordat, B., Verrey, F., and Kühn, L.C. (1999). LAT2: A new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J. Biol. Chem. 274, 34948-34954.

Saurin, J.C., Nemoz-Gaillard, E., Sordat, B., Cuber, J.C., Coy, D.H., Abello, J., and Chayvialle, J.A. (1999). Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line. Cancer Res. 59, 962-967.
Trumpp Andreas
Bates, B., Rios, M., Trumpp, A., Chen, C., Fan, G., Bishop, J. M., and Jaenisch, R. (1999). Neurotrophin-3 is required for proper cerebellar development. Nat Neurosci 2, 115-117. Abstract

Trumpp, A. (1999). Inhibitors in control: Cyclin Dependent Kinase (CDK) Inhibitors. Trends in Cell Biology 9, 122. Abstract

Trumpp, A., Depew, M. J., Rubenstein, J. L., Bishop, J. M., and Martin, G. R. (1999). Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev 13, 3136-3148. Abstract