Recherche cancer
Evolution cancer
Publications 2001
Aguet Michel
Zilian, O., Saner, C., Hagedorn, L., Lee, H.-Y., Säuberli, E., Suter, U., Sommer, L., and Aguet M. (2001). Multiple roles of mouse Numb in tuning developmental cell fates. Curr. Biol. 11, 494-501. Abstract

Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., Metzger, D., Chambon, P., Miele, L., Aguet, M., Radtke, F., and Dotto, G. P. (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J 20, 3427-3436. Abstract
Beard Peter
Raj, K., Ogston, P., and Beard, P. (2001). Virus-mediated killing of cells that lack p53 activity. Nature 412, 914-917. Abstract
Beermann Friedrich
Capone, M., Romagnoli, P., Beermann, F., MacDonald, H.R., and van Meerwijk, J.P. (2001). Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells. Blood 97, 1336-1342. Abstract

Camacho-Hübner, A., and Beermann, F. (2001). Increased transgene expression by the mouse tyrosinase enhancer is restricted to neural crest-derived pigment cells. Genesis 29, 180-187. Abstract

Ferrero, I., Wilson, A., Beermann, F., Held, W., and MacDonald, H.R. (2001). T cell receptor specificity is critical for the development of epidermal gammadelta T cells. J. Exp. Med. 194, 1473-1483. Abstract

Ioannidis, V., Beermann, F., Clevers, H., and Held, W. (2001). The ß-catenin - TCF-1 pathway ensures CD4+CD8+ thymocyte survival. Nature Immunol. 2, 691-697. Abstract

Ioannidis, V., Zimmer, J., Beermann, F., and Held, W. (2001). Cre recombinase-mediated inactivation of H-2Dd transgene expression: evidence for partial missing-self recognition by Ly49 NK cells. J. Immunol. 167, 6256-6262. Abstract

Kohler, S., Pradervand, S., Verdumo, C., Mérillat, A.M., Bens, M., Vandewalle, A., Beermann, F., and Hummler, E. (2001). Analysis of the mouse Scnn1a promoter in cortical collecting duct cells and in transgenic mice. Biochim. Biophys. Acta 1519, 106-110. Abstract

Miconnet, I., Coste, I., Beermann, F., Haeuw, J. F., Cerottini, J.C., Bonnefoy, J.Y., Romero, P., and Renno, T. (2001). Cancer vaccine design: a novel bacterial adjuvant for peptide-specific ctl induction. J. Immunol. 166, 4612-4619. Abstract

Murdoch, J.N., Rachel, R.A., Shah, S., Beermann, F., Stanier, P., Mason, C.A., and Copp, A.J. (2001). Circletail, a new mouse mutant with severe neural tube defects: Chromosomal localisation and interaction with the loop-tail mutation. Genomics 78, 55-63. Abstract

Pellieux, C., Foletti, A., Peduto, G., Aubert, J.F., Nussberger, J., Beermann, F., Brunner, H.R., and Pedrazzini, T. (2001) Dilated cardiomyopathy and impaired hypertrophic response to angiotensin II in mice lacking fibroblast growth factor-2. J. Clin. Invest. 108, 1843-1851. Abstract

Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., Lens, S., Cachero, T.G., Finke, D., Beermann, F., and Tschopp, J. (2001). Maturation of marginal zone and follicular B cells requires BAFF and is independent of BCMA. J. Exp. Med. 194, 1691-1697. Abstract
Bucher Philipp
Apweiler, R., Attwood, T.K., Bairoch, A., Bateman, A., Birney, E., Biswas, M., Bucher, P., Cerutti, L., Corpet, F., Croning, M.D., Durbin, R., Falquet, L., Fleischmann, W., Gouzy, J., Hermjakob, H., Hulo, N., Jonassen, I., Kahn, D., Kanapin, A., Karavidopoulou, Y., Lopez, R., Marx, B., Mulder, N.J., Oinn, T.M., Pagni, M., and Servant, F. (2001). The InterPro database, an integrated documentation resource for protein families, domains and functional sites.Nucleic Acids Res. 29, 37-40. Abstract

Deutsch, S., Iseli, C., Bucher, P., Antonarakis, S.E., and Scott, H.S. (2001). A cSNP Map and Database for Human Chromosome 21.Genome Res. 11, 300-307. Abstract

Ehret, G.B., Reichenbach, P., Schindler, U., Horvath, C.M., Fritz, S., Nabholz, M., and Bucher, P. (2001). DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites.J. Biol. Chem. 276, 6675-6688. Abstract

Green, A. J., Barcellos, L. F., Rimmler, J. B., Garcia, M. E., Caillier, S., Lincoln, R. R., Bucher, P., Pericak-Vance, M. A., Haines, J. L., Hauser, S. L., and Oksenberg, J. R. (2001). Sequence variation in the transforming growth factor-ß1 (TGFB1) gene and multiple sclerosis susceptibility. J Neuroimmunol 116, 116-124. Abstract

Hofmann, K., and Falquet, L. (2001). A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem Sci 26, 347-350. Abstract

Maryanski, J. L., Attuil, V., Hamrouni, A., Mutin, M., Rossi, M., Aublin, A., and Bucher, P. (2001). Individuality of Ag-selected and preimmune TCR repertoires. Immunol Res 23, 75-84. Abstract

Pagni, M., Iseli, C., Junier, T., Falquet, L., Jongeneel, V., and Bucher, P. (2001). trEST, trGEN and Hits: access to databases of predicted protein sequences.Nucleic Acids Res. 29, 148-151. Abstract

Junier, T., Pagni, M., and Bucher, P. (2001). Mmsearch: a motif arrangement language and search program. Bioinformatics 17, 1234-1235. Abstract
Delorenzi Mauro
 
Gönczy Pierre
Gönczy, P., Bellanger, J.-M., Kirkham, M., Pozniakowski, A., Baumer, K., Phillips, J.B., and Hyman, A.A. (2001). zyg-8, a gene required for spindle positioning in C. elegans, encodes a Doublecortin-related kinase that promotes microtubule assembly. Dev. Cell 1, 363-375. Abstract

Gönczy, P., Grill, S., Stelzer, E.H.K., Kirkham, M., and Hyman, A.A. (2001). Spindle positioning during the asymmetric first cell division of C. elegans embryos. Novartis Foundation Symposium 237, 164-175. Abstract

Grill, S.W., Gönczy, P., Stelzer, E.H., and Hyman, A.A. (2001). Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo. Nature 409, 630-633. Abstract
Garin Nathalie
Garin N. and Escher, G. (2001). The development of inhibitory synaptic specializations in the mouse deep cerebellar nuclei. Neuroscience 105, 431-441. Abstract

Pfend G., Matthieu J.M., Garin N., Tosic M. (2001). Implication of the extracellular disulfide bond on myelin protein zero expression. Neurochem Res. 26, 5, 503-10. Abstract

Zilian, O., Saner, C., Hagedorn, L., Lee, H.Y., Sauberli, E., Suter, U., Sommer, L., and Aguet, M. (2001). Multiple roles of mouse Numb in tuning developmental cell fates. Curr. Biol. 11, 494-501. Abstract
Gasser Susan
Cubizolles, F., and Gasser, S. M. (2001). The nucleosome: from wallflower to Queen of the Ball. Genome Biol. 2. More info

Dubrana, K., Perrod, S., and Gasser, S. M. (2001). Turning telomeres off and on. Curr. Opin. Cell Biol. 13, 281-289. More info

Gasser, S. M. (2001). Learning from yeast(s). Trends Genet 17, 358.

Gasser, S. M. (2001). Positions of potential: nuclear organization and gene expression. Cell 104, 639-642. More info

Gasser, S. M., and Cockell, M. M. (2001). The molecular biology of the SIR proteins. Gene 279, 1-16. More info

Heun, P., Laroche, T., Raghuraman, M. K., and Gasser, S. M. (2001). The positioning and dynamics of origins of replication in the budding yeast nucleus. J Cell. Biol. 152, 385-400. More info

Heun, P., Laroche, T., Shimada, K., Furrer, P., and Gasser, S. M. (2001). Chromosome dynamics in the yeast interphase nucleus. Science 294, 2181-2186. More info

Heun, P., Taddei, A., and Gasser, S. M. (2001). From snapshots to moving pictures: new perspectives on nuclear organization. Trends Cell. Biol. 11, 519-525. More info

Leroy, D., Kajava, A. V., Frei, C., and Gasser, S. M. (2001). Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA. Biochemistry 40, 1624-1634. More info

Maillet, L., Gaden, F., Brevet, V., Fourel, G., Martin, S. G., Dubrana, K., Gasser, S. M., and Gilson, E. (2001). Ku-deficient yeast strains exhibit alternative states of silencing competence. EMBO Rep 2, 203-210. More info

Pasero, P., and Gasser, S. M. (2001). In vitro DNA replication assays in yeast extracts. In Guide to Yeast Genetics, Molecular and Cell Biology, Part B, C. Guthrie and G. Fink, eds. (Methods in Enzymology). , pp. in press.

Perrod, S., Cockell, M. M., Laroche, T., Renauld, H., Ducrest, A. L., Bonnard, C., and Gasser, S. M. (2001). A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J 20, 197-209. More info

Trumpp, A., Refaeli, Y., Oskarsson, T., Gasser, S., Murphy, M., Martin, G. R., and Bishop, J. M. (2001). c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414, 768-773. More info
Grapin-Botton Anne
Grapin-Botton, A., Majithia, A.R., and Melton, D.M. (2001). Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 15, 444-454. Abstract
Huelsken Joerg
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., and Birchmeier, W. (2001). beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105, 533-545. Abstract

Huelsken, J., and Birchmeier, W. (2001). New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11, 547-553. Abstract
Iggo Richard
Brunori, M., Malerba, M., Kashiwazaki, H., and Iggo, R. (2001). Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. J. Virol. 75, 2857-2865. Abstract
Kühn Lukas C.
Kühn, L. C. (2001). The cytoplasmic fate of mRNA. J Cell Sci 114, 1797-1798.

Recalcati, S., Menotti, E., and Kühn, L. C. (2001). Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI. J Cell Sci 114, 1625-1629. Abstract

Recalcati, S., Menotti, E., and Kühn, L. C. (2001).Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI. J Cell Sci 114, 1625-1629. Full text
Kraehenbuhl Jean-Pierre
Coste, A., Cohen, J., Reinhardt, M., Kraehenbuhl, J., and Sirard, J. (2001). Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring. Vaccine 19, 4167-4174. More info

Debard, N., Sierro, F., Browning, J., and Kraehenbuhl, J.P. (2001). Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and m cells in mouse peyer's patches. Gastroenterology 120, 1173-1182. More info

Finke, D., and Kraehenbuhl, J. (2001). Formation of Peyer's patches. Curr Opin Genet Dev 11, 561-567. More info

Heppner, F. L., Christ, A. D., Klein, M. A., Prinz, M., Fried, M., Kraehenbuhl, J. P., and Aguzzi, A. (2001). Transepithelial prion transport by M cells.Nat Med 7, 976-977. More info

Kraehenbuhl, J. P. (2001). Development of plant vaccines: the point of view of the mucosal immunologist. In 25th International seminar on nuclear war and planetary emergencies, R. Ragaini, ed. (Nuclear strategy and peace technology). Erice (Italy): World scientific, pp. 112-123.

Kraehenbuhl, J. P. (2001). Mucosa-targeted DNA vaccination. Trends Immunol 22, 646-648. More info

Nardelli-Haefliger, D., Benyacoub, J., Lemoine, R., Hopkins-Donaldson, S., Potts, A., Hartman, F., Kraehenbuhl, J.P., and Grandi, P.D. (2001). Nasal vaccination with attenuated Salmonella typhimurium strains expressing the Hepatitis B nucleocapsid: dose response analysis. Vaccine 19, 2854-2861. More info

Neutra, M. R., Mantis, N. J., and Kraehenbuhl, J. P. (2001). Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol 2, 1004-1009. More info

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P., and Ricciardi-Castagnoli, P. (2001). Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2, 361-367. More info

Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J. P., and Sirard, J. C. (2001). Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci USA 98, 13722-13727. More info
Lingner Joachim
Damm, K., Hemmann, U., Garin-Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., Niestroj, C., Daiber, C., Enenkel, B., Guillard, B., Lauritsch, I., Müller, E., Pascolo, E., Sauter, G., Pantic, M., Martens, U. M., Wenz, C., Lingner, J., Kraut, N., Rettig, W. J., and Schnapp, A. (2001). A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20, 6958-6968. Abstract

Ducrest, A.-L., Amacker, M., Matthieu, Y., Reichenbach, P., Cuthbert, A.P., Trott, D.A., Newbold, R.F., Nabholz, M. and Lingner, J. (2001). Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity. Cancer Res. 61, 7594-7602. Abstract

Förstemann, K. and Lingner, J. (2001). Molecular basis for telomere repeat divergence in budding yeast. Mol. Cell. Biol. 21, 7277-7286. Abstract

Szutorisz, H., Palmquist, R., Roos, G., Stenling, R., Schorderet, D., Reddel, R., Lingner, J., and Nabholz, M. (2001). Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas. Oncogene 20, 2600-2665. Abstract

Wenz, C., Enenkel, B., Amacker, M., Kelleher, C., Damm, K., and Lingner, J. (2001). Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20, 3526-3534. Abstract
Peter Matthias
Galan, J.M., Wiederkehr, A., Seol, J.H., Haguenauer-Tsapis, R., Deshaies, R.J., Riezman, H., and Peter, M. (2001). Skp1p and the f-box protein rcy1p form a non-scf complex involved in recycling of the snare snc1p in yeast. Mol. Cell. Biol. 21, 3105-3117. More info

Gulli, M. P., and Peter, M. (2001). Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: the yeast perspective. Genes Dev. 15, 365-379. More info

Pintard, L., and Peter, M. (2001). Mitotic exit: closing the gap. Molecular Cell 8, 1155-1156. More info

Van Drogen, F., and Peter, M. (2001). MAP kinase dynamics in yeast. Biol Cell 93, 63-70. More info

Van Drogen, F., Stucke, V. M., Jorritsma, G., and Peter, M. (2001). MAP kinase dynamics in response to pheromones in budding yeast. Nat Cell Biol 3, 1051-1059. More info
Radtke Freddy
Wolfer, A., Bakker, T., Wilson, A., Nicolas, M., Ioannidis, V., Littman, D. R., Lee, P. P., Wilson, C. B., Held, W., MacDonald, H. R., and Radtke, F. (2001). Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol 2, 235-241. Abstract

Wilson, A., MacDonald, H. R., and Radtke, F. (2001). Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med 194, 1003-1012. Abstract

Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., Metzger, D., Chambon, P., Miele, L., Aguet, M., Radtke, F., and Dotto, G. P. (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. Embo J 20, 3427-3436. Abstract

MacDonald, H. R., Radtke, F., and Wilson, A. (2001). T cell fate specification and alphabeta/gammadelta lineage commitment. Curr Opin Immunol 13, 219-224. Abstract

MacDonald, H. R., Wilson, A., and Radtke, F. (2001). Notch1 and T-cell development: insights from conditional knockout mice. Trends Immunol 22, 155-160. Abstract
Simanis Viesturs
Cueille, N., Salimova, E., Esteban, V., Blanco, M., Moreno, S., Bueno, A., and Simanis, V. (2001). Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis. J Cell Sci 114, 2649-2664. Abstract

Fournier, N., Cerutti, L., Beltraminelli, N., Salimova, E., and Simanis, V. (2001). Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes. Arch. Microbiol. 175, 62-69. Abstract

Jouannic, S., Champion, A., Segui-Simarro, J. M., Salimova, E., Picaud, A., Tregear, J., Testillano, P., Risueno, M. C., Simanis, V., Kreis, M., and Henry, Y. (2001). The protein kinases AtMAP3Kepsilon1 and BnMAP3Kepsilon1 are functional homologues of S. pombe cdc7p and may be involved in cell division. Plant J 26, 637-649. Abstract

Krapp, A., Schmidt, S., Cano, E., and Simanis, V. (2001). S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body. Curr Biol 11, 1559-1568. Abstract

Le Goff, X., Buvelot, S., Salimova, E., Guerry, F., Schmidt, S., Cueille, N., Cano, E., and Simanis, V. (2001). The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network. FEBS Lett 508, 136-142. Abstract
Sordat Bernard
Burri, N., Shaw, P., Bouzourene, H., Sordat, I., Sordat, B., Gillet, M., Schorderet, D., Bosman, F.T., and Chaubert, P. (2001). Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. Lab. Invest. 81, 217-229. More info

Lahm, H., Andre, S., Hoeflich, A., Fischer, J. R., Sordat, B., Kaltner, H., Wolf, E., and Gabius, H. J. (2001). Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J Cancer Res. Clin. Oncol. 127, 375-386. More info

Trumpp Andreas
Fan, G., Beard, C., Chen, R.Z., Csankovszki, G., Sun, Y., Siniaia, M., Biniszkiewicz, D., Bates, B., Lee, P.P., Kuhn, R., Trumpp, A., Poon, C., Wilson, C.B., and Jaenisch, R. (2001). DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21, 788-797. Abstract

Groszer, M., Erickson, R., Lesche, R., Trumpp, A., Kornblum, H., Wu, H., and Liu, X. (2001). Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186-2189. Abstract

Trumpp, A., Refaeli, Y., Oskarsson, T., Gasser, S., Murphy, M., Martin, G.R. and Bishop, J.M. (2001). c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414, 768-773. Abstract