Publications 2002
Aguet Michel
Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K. A., and Mantei, N. (2002). Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol 158, 709-718. Abstract

Lütolf, S., Radtke, F., Aguet, M., Suter, U., and Taylor, V. (2002). Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 129, 373-385. Abstract
Beard Peter

Raj, K., Ogston, P., and Beard, P. (2002). Addendum: Virus-mediated killing of cells that lack p53 activity. Nature 416, 202. Abstract

Davy, CE, Jackson, DJ, Wang, Q, Raj, K, Masterson, PJ, Fenner, NF, Southern, S, Cuthill, S, Millar, JB, and Doorbar, J (2002). Identification of a G(2) arrest domain in the E1-E4 protein of human papillomavirus type 16. J Virol 76, 9806-9818. Abstract
Beermann Friedrich
Beck, S., Le Good, A.J., Guzman, M., Ben Haim, N., Roy, K., Beermann, F., and Constam, D.B. (2002) Extraembryonic proteases regulate Nodal signaling during gastrulation. Nat. Cell Biol. 4:981-985. Abstract

Beermann, F., Camacho-Hübner, A. (2002). Biology of pigmentation: Tyrosinase and gene regulation in transgenic mice. Recent Res. Devel. Biol. Chem. 1, 73-92.

Camacho-Hübner, A., Richard, C., and Beermann, F. (2002). Genomic structure and evolutionary conservation of the tyrosinase gene family from Fugu. Gene 285, 59-68. Abstract

Foletti, A., Ackermann, J., Schmidt, A., Hummler, E., and Beermann, F. (2002). Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE. Oncogene 21, 1841-1847. Abstract

Guyonneau, L., Rossier, A., Richard, C., Hummler, E., Beermann, F. (2002) Expression of Cre recombinase in pigment cells. Pigment Cell Res 15, 305-309. Abstract

Hummler, E., Merillat, A. M., Rubera, I., Rossier, B. C., and Beermann, F. (2002). Conditional gene targeting of the Scnn1a (aENaC)  gene locus. Genesis 32, 169-172. Abstract

Lens, S.M., Kataoka, T., Fortner, K.A., Tinel, A., Ferrero, I., MacDonald, R.H., Hahne, M., Beermann, F., Attinger, A., Acha-Orbea, H., Budd, R.C., and Tschopp, J. (2002). The Caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol. Cell. Biol. 22, 5419-5433. Abstract

Rachel, R.A., Mason, C.A., Beermann, F. (2002) Influence of tyrosinase levels on pigment accumulation in the retinal pigment epithelium and on the uncrossed retinal projection. Pigment Cell Res 15, 273-281. Abstract

Rachel, R. A., Wellington, S. J., Warburton, D., Mason, C. A., and Beermann, F. (2002). A new allele of Gli3 and a new mutation, circletail (CRC), resulting from a single transgenic experiment. Genesis 33, 55-61. Abstract

Rubera, I., Meier, E., Vuagniaux, G., Merillat, A. M., Beermann, F., Rossier, B. C., and Hummler, E. (2002). A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus. Genesis 32, 173-176. Abstract
Brisken Cathrin
Brisken, C., Ayyannan, A., Doppler,W. (2002). Prolactin signaling and Stat5: going their own separate ways? Breast Cancer Res. 4, 209-212. Abstract

Brisken, C., Ayyannan, A., Nguyen, C., Heineman, A., Reinhardt, F., Tan, J., Dey, S.K., Dotto, G. P., Weinberg, R.A. (2002). IGF-2 is a mediator of prolactin-induced proliferation/morphogenesis in the breast. Dev Cell. 3, 877-887. Abstract

Brisken, C. (2002). Hormonal control of alveolar development and its implications for breast carcinogenesis. J. Mammary Gland Biol Neoplasia. 7, 39-48. Abstract

Brisken, C., Socolovsky, M., Lodish, H. F., and Weinberg, R. (2002). The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci U S A. 99, 14241-14245. Abstract
Bucher Philipp
Dermitzakis, E. T., Reymond, A., Lyle, R., Scamuffa, N., Ucla, C., Deutsch, S., Stevenson, B. J., Flegel, V., Bucher, P., Jongeneel, C. V., and Antonarakis, S. E. (2002). Numerous potentially functional but non-genic conserved sequences on human chromosome 21. Nature 420, 578-582. Abstract

Falquet, L., Pagni, M., Bucher, P., Hulo, N., Sigrist, C. J., Hofmann, K., and Bairoch, A. (2002). The PROSITE database, its status in 2002. Nucleic Acids Res 30, 235-238. Abstract

Iseli, C., Stevenson, B. J., de Souza, S. J., Samaia, H. B., Camargo, A. A., Buetow, K. H., Strausberg, R. L., Simpson, A. J., Bucher, P., and Jongeneel, C. V. (2002). Long-range heterogeneity at the 3' ends of human mRNAs. Genome Res 12, 1068-1074. Abstract

Mulder, N. J., Apweiler, R., Attwood, T. K., Bairoch, A., Bateman, A., Binns, D., Biswas, M., Bradley, P., Bork, P., Bucher, P., Copley, R., Courcelle, E., Durbin, R., Falquet, L., Fleischmann, W., Gouzy, J., Griffith-Jones, S., Haft, D., Hermjakob, H., Hulo, N., Kahn, D., Kanapin, A., Krestyaninova, M., Lopez, R., Letunic, I., Orchard, S., Pagni, M., Peyruc, D., Ponting, C. P., Servant, F., Sigrist, C. J. (2002). InterPro: an integrated documentation resource for protein families, domains and functional sites. Brief Bioinform 3, 225-235. Abstract

Praz, V., Cavin-Périer, R., Bonnard, C., and Bucher, P. (2002). The Eukaryotic Promoter Database, EPD: new entry types and links to gene expression data. Nucleic Acids Res 30, 322-324. Abstract

Reymond, A., Camargo, A. A., Deutsch, S., Stevenson, B. J., Parmigiani, R. B., Ucla, C., Bettoni, F., Rossier, C., Lyle, R., Guipponi, M., de Souza, S., Iseli, C., Jongeneel, C. V., Bucher, P., Simpson, A. J., Antonarakis, S. E. (2002). Nineteen additional unpredicted transcripts from human chromosome 21. Genomics 79, 824-832. Abstract

Roulet, E., Busso, S., Camargo, A. A., Simpson, A. J., Mermod, N., and Bucher, P. (2002). High-throughput SELEX SAGE method for quantitative modeling of transcription-factor binding sites. Nat Biotechnol 20, 831-835. Abstract

Sigrist, C. J., Cerutti, L., Hulo, N., Gattiker, A., Falquet, L., Pagni, M., Bairoch, A., and Bucher, P. (2002). PROSITE: a documented database using patterns and profiles as motif descriptors. Brief Bioinform 3, 265-274. Abstract
Constam Daniel
Beck, S., Le Good, A.J., Guzman, M., Ben Haim, N., Roy, K., Beermann, F., and Constam, D.B. (2002) Extraembryonic proteases regulate Nodal signaling during gastrulation. Nat. Cell Biol. 4, 981-985.  Abstract
Delorenzi Mauro
Delorenzi M and Speed T (2002). An HMM model for coiled-coil domains and a comparison with PSSM-based predictions. Bioinformatics. 18, 617-625. Abstract

Miller SK, Good RT, Drew DR, Delorenzi M, Sanders PR, Hodder AN, Speed TP, Cowman AF, de Koning-Ward TF, Crabb BS. (2002). A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem. 277, 47524-32. Abstract

Delorenzi M, Sexton A, Shams-Eldin H, Schwarz R, Speed T, Schofield L (2002). Genes For Glycosylphosphatidylinositol Toxin Biosynthesis In Plasmodium falciparum. Infect. Immun. 70, 4510-4522. Abstract
Gönczy Pierre
Gönczy, P. (2002). Mechanisms of spindle positioning: focus on flies and worms. Trends Cell Biol 12, 332-339. Abstract

Gönczy, P. (2002). Nuclear envelope: torn apart at mitosis. Curr Biol 12, R242-244. Abstract

Hannak, E., Oegema, K., Kirkham, M., Gönczy, P., Habermann, B., and Hyman, A. A. (2002). The kinetically dominant assembly pathway for centrosomal asters in C. elegans is gamma-tubulin dependent. J Cell Biol 157, 591-602. Abstract

Kurz, T., Pintard, L., Willis, J. H., Hamill, D. R., Gönczy, P., Peter, M., and Bowerman, B. (2002). Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298. Abstract
Garin Nathalie
Garin, N., Hornung, J.P., and Escher, G. (2002). Distribution of postsynaptic GABA(A) receptor aggregates in the deep cerebellar nuclei of normal and mutant mice. J. Comp. Neurol. 447, 210-217. Abstract
Grapin-Botton Anne
Johansson, K. A., and Grapin-Botton, A. (2002). Development and diseases of the pancreas. Clin. Genet. 62, 14-23. Abstract

Grapin-Botton, A. (2002). Les étapes du développement du pancréas: des pistes pour le traitement du diabète. Médecine/Sciences 18, 467-473.
Huelsken Joerg
Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuhl, M., Schaeffer, H. J., Huelsken, J., Behrens, J., Hammerschmidt, M., and Birchmeier, W. (2002). The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev 16, 2073-2084. Abstract

Wong, M. H., Huelsken, J., Birchmeier, W., and Gordon, J. I. (2002). Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling. J Biol Chem 277, 15843-15850. Abstract

Niemann, C., Owens, D. M., Hulsken, J., Birchmeier, W., and Watt, F. M. (2002). Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development 129, 95-109. Abstract

Huelsken, J., and Behrens, J. (2002). The Wnt signalling pathway. J Cell Sci 115, 3977-3978. Abstract
Iggo Richard
Bonnefoi, H., Ducraux, A., Movarekhi, S., Pelte, M. F., Bongard, S., Lurati, E., and Iggo, R. (2002). p53 as a potential predictive factor of response to chemotherapy: feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients. Br J Cancer 86, 750-755. Abstract

Fuerer, C., and Iggo, R. (2002). Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway. Gene Ther 9, 270-281. Abstract

Kaeser, M. D., and Iggo, R. D. (2002). Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity invivo. Proc Natl Acad Sci U S A 99, 95-100. Abstract
Kühn Lukas C.
Marziali, G., Perrotti, E., Ilari, R., Lulli, V., Coccia, E. M., Mazzeo, S., Kühn, L. C., Testa, U., and Battistini, A. (2002). Role of ets-1 in erythroid differentiation. Blood Cells Mol Dis 29, 553-561. Abstract

Marziali, G., Perrotti, E., Ilari, R., Lulli, V., Coccia, E. M., Moret, R., Kühn, L. C., Testa, U., and Battistini, A. (2002). Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation. Oncogene 21, 7933-7944. Abstract
Kraehenbuhl Jean-Pierre
Didierlaurent, A., Sirard, J. C., Kraehenbuhl, J. P., and Neutra, M. R. (2002). How the gut senses its content. Cell Microbiol 4, 61-72. More info

Finke, D., Acha-Orbea, H., Mattis, A., Lipp, M., and Kraehenbuhl, J.-P. (2002). CD4(+)CD3(-) Cells induce Peyer's Patch development. Role of a4b1 integrin activation by CXCR5. Immunity 17, 363. More info

Fotopoulos, G., Harari, A., Michetti, P., Trono, D., Pantaleo, G., and Kraehenbuhl, J. P. (2002). Transepithelial transport of HIV-1 by M cells is receptor-mediated. Proc Natl Acad Sci U S A 99, 9410-9414. More info

Neutra, M. R., and Kraehenbuhl, J.-P. (2002). The regional immune response to microbial pathogens. In Immunology of infectious diseases, S.H.E. Kaufmann, A. Sher, and R. Ahmed, ed. (Washington, D.C., ASM Press), pp. 191-206.

Neutra, M. R., Sansonetti, P., and Kraehenbuhl, J. P. (2002). Interactions of microbial pathogens with intestinal M cells. In Infections of the gastrointestinal tract, M. J. Blaser [et al.] eds. (Philadelphia, Lippincott, Williams & Wilkins), pp. 141-156.

Phalipon, A., Cardona, A., Kraehenbuhl, J. P., Edelman, L., Sansonetti, P. J., and Corthésy, B. (2002). Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17, 107-115. More info
Lingner Joachim
Ducrest, A. L., Amacker, M., Lingner, J., and Nabholz, M. (2002). Detection of promoter activity by flow cytometric analysis of GFP reporter expression. Nucleic Acids Res 30, e65. Abstract

Ducrest, A. L., Szutorisz, H., Lingner, J., and Nabholz, M. (2002). Regulation of the human telomerase reverse transcriptase gene. Oncogene 21, 541-552. Abstract

Kelleher, C., Teixeira, M. T., Förstemann, K., and Lingner, J. (2002). Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem Sci 27, 572-579. Abstract

Lingner, J., and Wenz, C. (2002). The makings of telomerases. In: Telomeres and Telomerases: Cancer and Biology, G. Krupp and R. Parwaresch, eds. (Landes Bioscience).

Pascolo, E., Wenz, C., Lingner, J., Hauel, N., Priepke, H., Kauffmann, I., Garin-Chesa, P., Rettig, W. J., Damm, K., and Schnapp, A. (2002). Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem 277, 15566-15572. Abstract

Teixeira, M. T., Förstemann, K., Gasser, S. M., and Lingner, J. (2002). Intracellular trafficking of yeast telomerase components. EMBO Rep 3, 652-659. Abstract
Naef Félix
Naef, F., Hacker, C., Patil, N., and Magnasco, M. (2002). Characterization of the expression ratio noise structure in high-density oligonucleotide arrays. Genome Biol. 3, RESEARCH0018. Abstract

Naef, F., Lim, D.A., Patil, N., and Magnasco, M. (2002). DNA hybridization to mismatched templates: a chip study. Phys. Rev. E 65, 040902. Abstract

Bourdon, V., Naef, F., Rao, P.H., Reuter, V., Mok, S., Bosl, G.J., Koul, S., Murty, V.V.V.S., Kucherlapati, R., and Chaganti, R.S.K. (2002). Genomic and expression analysis of the 12p11 p12 amplicon using EST arrays identifies two novelamplified and over-expressed genes. Cancer Res. 62, 6218-6223.  Abstract
Peter Matthias
Butty, A. C., Perrinjaquet, N., Petit, A., Jaquenoud, M., Segall, J. E., Hofmann, K., Zwahlen, C., and Peter, M. (2002). A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization. EMBO J 21, 1565-1576. More info

Chang, F., and Peter, M. (2002). Cell biology. Formins set the record straight. Science 297, 531-532. More info

Jaquenoud, M., van Drogen, F., and Peter, M. (2002). Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1). EMBO J 21, 6515-6526. More info

Kurz, T., Pintard, L., Willis, J. H., Hamill, D. R., Gönczy, P., Peter, M., and Bowerman, B. (2002). Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298. More info

van Drogen, F., and Peter, M. (2002). MAP kinase cascades: scaffolding signal specificity. Curr Biol 12, R53-55. More info

van Drogen, F., and Peter, M. (2002). Spa2p functions as a scaffold-like protein to recruit the Mpk1p MAP kinase module to sites of polarized growth. Curr Biol 12, 1698. More info
Radtke Freddy
Wolfer, A., Wilson, A., Nemir, M., MacDonald, H. R., and Radtke, F. (2002). Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity 16, 869-879. Abstract

Radtke, F., Wilson, A., Ernst, B., and MacDonald, H. R. (2002). The role of Notch signaling during hematopoietic lineage commitment. Immunol Rev 187, 65-74. Abstract

Lutolf, S., Radtke, F., Aguet, M., Suter, U., and Taylor, V. (2002). Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 129, 373-385. Abstract

Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K. A., and Mantei, N. (2002). Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol 158, 709-718. Abstract

Ferrero, I., Held, W., Wilson, A., Tacchini-Cottier, F., Radtke, F., and MacDonald, H. R. (2002). Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage. Blood 100, 2852-2857. Abstract
Rufer Nathalie
Einsele, H., Roosnek, E., Rufer, N., Sinzger, C., Riegler, S., Loffler, J., Grigoleit, U., Moris, A., Rammensee, H. G., Kanz, L., et al. (2002). Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 99, 3916-3922. Abstract

Kwak, B. R., Myit, S., Mulhaupt, F., Veillard, N., Rufer, N., Roosnek, E., and Mach, F. (2002). PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. Circ Res 90, 356-362. Abstract

Romero, P., Valmori, D., Pittet, M. J., Zippelius, A., Rimoldi, D., Lévy, F., Dutoit, V., Ayyoub, M., Rubio-Godoy, V., Michielin, O., Guillaume, P., Batard, P., Luescher, I.F., Lejeune, F., Lienard, D.,  Rufer, N., Dietrich, P.Y., Speiser, D.E. and Cerottini, J.-C.(2002). Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma. Immunol Rev 188, 81-96. Abstract

Zippelius, A., Pittet, M. J., Batard, P., Rufer, N., de Smedt, M., Guillaume, P., Ellefsen, K., Valmori, D., Lienard, D., Plum, J., et al. (2002). Thymic selection generates a large T cell pool recognizing a self-peptide in humans. J Exp Med 195, 485-494. Abstract
Simanis Viesturs
Poloni, D., and Simanis, V. (2002). A DMSO-sensitive conditional mutant of the fission yeast orthologue of the Saccharomyces cerevisiae SEC13 gene is defective in septation. FEBS Lett 511, 85-89. Abstract
Sordat Bernard
Saurin, J. C., Fallavier, M., Sordat, B., Gevrey, J. C., Chayvialle, J. A., and Abello, J. (2002). Bombesin stimulates invasion and migration of Isreco1 colon carcinoma cells in a Rho-dependent manner. Cancer Res 62, 4829-4835. More info 

Sordat, I., Decraene, C., Silvestre, T., Petermann, O., Aufray, C., Pietu, G., and Sordat, B. (2002). cDNA arrays identify CD63 tetraspanin and alpha3 integrin chain as differentially expressed in low and high metastatic human colon carcinoma cells. Lab Invest, 82, 1715-1724. More info


Trumpp Andreas
Trumpp, A. (2002). After 25 years of research into the proto-oncogene c-myc, there is a light at the end of the tunnel. Bull Suisse Cancer 22, 34-37.