Cancer research
Cancer development
Publications 2003
Beard Peter
Bechtold, V., Beard, P., and Raj, K. (2003). Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA. J Virol 76, 2021-2028. Abstract

Lathion, S, Schaper, J, Beard, P, Raj, K (2003). Notch1 can contribute to viral-induced transformation of primary human keratinocytes. Cancer Res 63, 8687-8694. Abstract

Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, P., van Noort, M., Hui, C.C., Clevers, H., Dotto, G.P., and Radtke, F (2003). Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33, 416-421. Abstract

Radtke, F, and Raj, K (2003). The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 3, 756-767. Abstract
Beermann Friedrich
Beermann, F, Rossier, A, Guyonneau, L (2003). SP-09 Inactivation of the mouse Dct gene. Pigment Cell Res 16, 577-578. Full text

Capone, M., Cantarella, D., Schümann, J., Naidenko, O.V., Garavaglia, C., Beermann, F., Kronenberg, M., Dellabona, P., MacDonald, H.R., and Casorati, G. (2003) Human invariant Va24-JaQ TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. J Immunol 170, 2390-2398. Abstract

Foletti, A., Vuadens, F., and Beermann, F. (2003). Nuclear localization of mouse fibroblast growth factor 2 requires N-terminal and C-terminal sequences. Cell Mol Life Sci 60(10): 2254-65. Abstract

Voyle, R. B., Beermann, F., Lees, R. K., Schumann, J., Zimmer, J., Held, W., and MacDonald, H. R. (2003). Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D. J Exp Med 197, 919-925. Abstract

Capone, M., Cantarella, D., Schumann, J., Naidenko, O. V., Garavaglia, C., Beermann, F., Kronenberg, M., Dellabona, P., MacDonald, H. R., and Casorati, G. (2003). Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. J Immunol 170, 2390-2398. Abstract
Brisken Cathrin
Gass, S, Harris, J, Ormandy, C, and Brisken, C. (2003). Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function. J Mammary Gland Biol Neoplasia. 8, 269-285 Abstract
Bucher Philipp
Ambrosini, G., Praz, V., Jagannathan, V., and Bucher, P. (2003). Signal search analysis server. Nucleic Acids Res 31, 3618-3620. Abstract

Beernink, H. T., Miller, K., Deshpande, A., Bucher, P., and Cooper, J. P. (2003). Telomere maintenance in fission yeast requires an est1 ortholog. Curr Biol 13, 575-580. Abstract

Godard, S., Getz, G., Delorenzi, M., Farmer, P., Kobayashi, H., Desbaillets, I., Nozaki, M., Diserens, A. C., Hamou, M. F., Dietrich, P. Y., Regli, L., Janzer, R. C., Bucher, P., Stupp, R., de Tribolet, N., Domany, E., and Hegi, M. E. (2003). Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res 63, 6613-25. Abstract

Lottaz, C., Iseli, C., Jongeneel, C. V., and Bucher, P. (2003). Modeling sequencing errors by combining Hidden Markov models. Bioinformatics 19 Suppl 2, II103-II112. Abstract

Mulder, N. J., Apweiler, R., Attwood, T. K., Bairoch, A., Barrell, D., Bateman, A., Binns, D., Biswas, M., Bradley, P., Bork, P., Bucher, P., Copley, R. R., Courcelle, E., Das, U., Durbin, R., Falquet, L., Fleischmann, W., Griffiths-Jones, S., Haft, D., Harte, N., Hulo, N., Kahn, D., Kanapin, A., Krestyaninova, M., Lopez, R., Letunic, I., Lonsdale, D., Silventoinen, V., Orchard, S. E., Pagni, M., Peyruc, D., Ponting, C. P., Selengut, J. D., Servant, F., Sigrist, C. J., Vaughan, R., and Zdobnov, E. M. (2003). The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31, 315-318. Abstract

O'Sullivan, O., Zehnder, M., Higgins, D., Bucher, P., Grosdidier, A., and Notredame, C. (2003). APDB: a novel measure for benchmarking sequence alignment methods without reference alignments. Bioinformatics 19 Suppl 1, I215-I221. Abstract

Reichenbach, P., Hoss, M., Azzalin, C. M., Nabholz, M., Bucher, P., and Lingner, J. (2003). A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol 13, 568-574. Abstract
Constam Daniel
Constam, D.B. (2003). Watch thy neighbor: Proprotein convertases activate TGFβ-related signals across tissue boundaries. Bulletin Suisse du Cancer 23, 3, 141-144.
Delorenzi Mauro
Godard, S., Getz, G., Delorenzi, M., Farmer, P., Kobayashi, H., Desbaillets, I., Nozaki, M., Diserens, A.C., Hamou, M.F., Dietrich, P.Y., Regli, L., Janzer, R.C., Bucher, P., Stupp, R., de Tribolet, N., Domany, E., Hegi, M.E. (2003). Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res 63, 6613-6625. Abstract

Hodder, A.N., Drew, D., Epa, V.C., Delorenzi, M., Bourgon, R., Miller, S.K., Moritz, R.L., Frecklington, D.F., Simpson, R.J., Speed, T.P., Pike, R.N., Crabb, B.S. (2003). Enzymic, phylogenetic and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5. J Biol Chem 278, 48169-48177. Abstract
Gönczy Pierre
Bellanger, J.M., Gönczy, P. (2003). TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos.  Curr Biol. 13, 1488-1498. Abstract

Brauchle, M., Baumer, K., Gönczy, P. (2003). Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Curr Biol. 13, 819-27. Abstract

Colombo, K., Grill, S.W., Kimple, R.J., Willard, F.S., Siderovski, D.P., Gönczy, P. (2003).Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science 300, 1957-1961. Abstract

Gönczy, P. (2003). Mechanisms of cell division: lessons from a nematode. Med Sci (Paris). 19, 735-42. Abstract

Leidel, S., and Gönczy, P. (2003). SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. Dev Cell 4, 431-439. Abstract
Grapin-Botton Anne
Kumar, M., Jordan, N., Melton, D., and Grapin-Botton, A. (2003). Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol 259, 109-122. Abstract
Huelsken Joerg
Bamji, S X, Shimazu, K, Kimes, N, Huelsken, J, Birchmeier, W, Lu, B, Reichardt, L F (2003). Role of b-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40, 719-731. Abstract

Morkel, M, Huelsken, J, Wakamiya, M, Ding, J, van de Wetering, M, Clevers, H, Taketo, M M, Behringer, R R, Shen, M M, Birchmeier, W (2003). b-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130, 6283-6294. Abstract

Mucenski, M. L., Wert, S. E., Nation, J. M., Loudy, D. E., Huelsken, J., Birchmeier, W., Morrisey, E. E., and Whitsett, J. A. (2003). beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278, 40231-40238. Abstract

Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R. R., Taketo, M. M., Crenshaw, E. B., 3rd, and Birchmeier, W. (2003). Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev 17, 1963-1968. Abstract

Xu, Y, Banerjee, D, Huelsken, J, Birchmeier, W, Sen, J M (2003). Deletion of b-catenin impairs T cell development. Nat Immunol 4, 1177-1182. Abstract

Zechner, D., Fujita, Y., Huelsken, J., Muller, T., Walther, Taketo, M. M., Crenshaw, E. B. 3rd, Birchmeier, W. and Birchmeier, C. (2003). beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol 258, 406-418. Abstract
Iggo Richard
Bridge, A. J., Pebernard, S., Ducraux, A., Nicoulaz, A. L., and Iggo, R. (2003). Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34, 263-264. Abstract

Butticaz, C, Ciuffi, A, Munoz, M, Thomas, J, Bridge, A, Pebernard, S, Iggo, R, Meylan, P, Telenti, A (2003). Protection from HIV-1 infection of primary CD4 T cells by CCR5 silencing is effective for the full spectrum of CCR5 expression. Antivir Ther 8, 373-377. Abstract

Chao, C., Hergenhahn, M., Kaeser, M. D., Wu, Z., Saito, S., Iggo, R., Hollstein, M., Appella, E., and Xu, Y. (2003). Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem 278, 41028-41033. Abstract

Malerba, M., Daeffler, L., Rommelaere, J., and Iggo, R. D. (2003). Replicating parvoviruses that target colon cancer cells. J Virol 77, 6683-6691. Abstract
Kühn Lukas C.
Kühn, L. C. (2003). Regulation of mRNA translation and stability in iron metabolism : is there a redox switch? In : Cellular implications of redox signaling, C. Gitler, and A. Danon, eds. (Imperial College Press).
Kraehenbuhl Jean-Pierre
Anderle, P., Duval, M., Draghici, S., Kuklin, A., Littlejohn, T. G., Medrano, J. F., Vilanova, D., and Roberts, M. A. (2003). Gene expression databases and data mining. Biotechniques Suppl, 36-44. More info

Anderle, P., Rakhmanova, V., Woodford, K., Zerangue, N., and Sadee, W. (2003). Messenger RNA expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines. Pharm Res 20, 3-15. More info

Corthésy-Theulaz, I., Corthésy, B., Bachmann, D., Velin, D., and Kraehenbuhl, J. P. (2003). Passive immunity in helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning. Infect Immun 71, 2226-2229. More info

Mpandi, M., Otten, L. A., Lavanchy, C., Acha-Orbea, H., and Finke, D. (2003). Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle. J Virol 77, 9369-9377. More info

Neutra, M. R., Sansonetti, P., and Kraehenbuhl, J.-P. (2003). Role of intestinal M cells in microbial pathogenesis. In Microbial pathogenesis and the intestinal epithelial cell, G. Hecht, ed. (Washington, D.C., ASM Press), pp. 23-42.

Ramirez, J. C., Finke, D., Esteban, M., Kraehenbuhl, J. P., and Acha-Orbea, H. (2003). Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration. Arch Virol 148, 827-839. More info

Lingner Joachim
Cristofari, G., and Lingner, J. (2003). Fingering the ends. How to make new telomeres. Cell 113, 552-554. Abstract

Förstemann, K., Zaug, A. J., Cech, T. R., and Lingner, J. (2003). Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 31, 1646-1655. Abstract

Reichenbach, P., Höss, M., Azzalin, C. M., Nabholz, M., Bucher, P., and Lingner, J. (2003). A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Current Biology 13, 568-574. Abstract

Szutorisz, H., Lingner, J., Cuthbert, A. P., Trott, D. A., Newbold, R. F. and Nabholz, M. (2003). A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin. Cancer Res. 63, 689-695. Abstract
Naef Félix
Naef, F., Socci, N., and Magnasco, M. (2003). A study of accuracy and precision in oligonucleotide arrays: extracting more signal at large concentrations. Bioinformatics 19, 178-184. Abstract

Hekstra, D., Taussig, A.R., Magnasco, M., Naef, F. (2003). Absolute mRNA concentrations from sequence-specific calibration of oligonucleotide arrays. Nucleic Acids Res. 31, 1962-1968. Abstract

Naef, F., and Magnasco, M. (2003). Solving the riddle of the bright mismatches: the physics of hybridization. Phys. Rev. E68, 011906. Abstract

Sato, N., Munoz Sanjuan, I., Heke, M., Uchida, M., Naef, F., and Brivanlou, A.H. (2003). Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev. Biol. 260, 404-413. Abstract

Asmal, M., Colgan, J., Naef, F., Yu, B., Lee, Y., Magnasco, M., Luban, J. (2003). Production of ribosome components in effector CD4+ T cells is accelerated by TCR stimulation and coordinated by ERK MAPK. Immunity 19, 535-548. Abstract
Radtke Freddy
Radtke, F., and Raj, K. (2003). The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 3, 756-767. Abstract

Pear, W. S., and Radtke, F. (2003). Notch signaling in lymphopoiesis. Semin Immunol 15, 69-79. Abstract

Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C. C., Clevers, H., Dotto, G. P., and Radtke, F. (2003). Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33, 416-421. Abstract
Rufer Nathalie
Bigouret, V., Hoffmann, T., Arlettaz, L., Villard, J., Colonna, M., Ticheli, A., Gratwohl, A., Samii, K., Chapuis, B., Rufer, N., and Roosnek, E. (2003). Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors. Blood 101, 3198-3204. Abstract

Rufer, N. and M. Nabholz (2003). [Telomerase, elixir of life for human cells?]. Med Sci (Paris) 19, 345-350. Abstract

Rufer, N., Zippelius, A., Batard, P., Pittet, M. J., Kurth, I., Corthésy, P., Cerottini, J. C., Leyvraz, S., Roosnek, E., Nabholz, M., and Romero, P. (2003). Ex-vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions. Blood 102, 1779-1787. Abstract

Sauce, D., Rufer, N., Mercier, P., Bodinier, M., Rémy-Martin, J. P., Duperrier, A., Ferrand, C., Herve, P., Romero, P., Lang, F., Tiberghien, P. and Robinet, E. (2003). Retrovirus-mediated gene transfer in polyclonal T cells results in lower apoptosis and enhanced ex vivo cell expansion of CMV-reactive CD8 T cells as compared to EBV-reactive CD8 T cells. Blood 102, 1241-1248. Abstract
Simanis Viesturs
Krapp, A., Cano, E., and Simanis, V. (2003). Mitotic Hyperphosphorylation of the Fission Yeast SIN Scaffold Protein cdc11p Is Regulated by the Protein Kinase cdc7p. Curr Biol 13, 168-172. Abstract

Simanis, V. (2003). Events at the end of mitosis in the budding and fission yeasts. J Cell Sci 116, 4263-4275. Abstract

Simanis, V. (2003). The mitotic exit and septation initiation networks. J Cell Sci 116, 4261-4262. Abstract
Sordat Bernard
Lahm, H., André S., Hoeflich, A., Fischer, J. R., Sordat, B., Kaltner, H., Wolf, E., and Gabius, H. J.  (2003). Molecular biological fingerprinting of human lectin expression by RT-PCR. Methods Enzymol 362, 287-97. More info
Trumpp Andreas
Crone, S. A., Negro, A., Trumpp, A., Giovannini, M., and Lee, K. F. (2003). Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron 37, 29-40. Abstract

MacPherson D., Sage J., Crowley D., Trumpp A., Bronson RT., and Jacks T. (2003). Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol 23, 1044-1053. Abstract