The microbiota-eosinophil axis as a critical regulator of disease course, metastasis and therapy response in patients with colorectal cancer

Colorectal cancer (CRC) is the second most common cancer and cause of cancer-related deaths worldwide. Epidemiological studies have linked the presence of high intratumoral eosinophil levels to favorable prognosis and enhanced survival of CRC patients. However, the underlying mechanisms for this remain poorly understood. Within our project, we aim to understand whether alterations in the intestinal microbiota composition – a hallmark of CRC patients – might modulate eosinophil functions within the tumor microenvironment, thus affecting disease course, the development of metastasis and therapeutic response in CRC patients. We aim to provide new avenues for harnessing eosinophil activities in CRC and will foster personalized microbiota-based precision medicine strategies for patient care.