{"id":3595,"date":"2022-10-24T11:38:00","date_gmt":"2022-10-24T09:38:00","guid":{"rendered":"https:\/\/www.isrec.ch\/recherche\/tcr-engineered-cd4-t-cell-transfer-for-optimized-cancer-immunotherapy-in-adult-and-pediatric-patients\/"},"modified":"2026-05-28T15:43:40","modified_gmt":"2026-05-28T13:43:40","slug":"tcr-engineered-cd4-t-cell-transfer-for-optimized-cancer-immunotherapy-in-adult-and-pediatric-patients","status":"publish","type":"recherche","link":"https:\/\/www.isrec.ch\/en\/research\/tcr-engineered-cd4-t-cell-transfer-for-optimized-cancer-immunotherapy-in-adult-and-pediatric-patients\/","title":{"rendered":"<strong>Pediatric leukemia<\/strong> &#8211; Prof. Camilla Jandus (UNIGE), Dr. Francesco Ceppi and Prof. George Coukos (CHUV)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">TCR-engineered CD4 T cell transfer for optimized cancer immunotherapy in adult and pediatric patients<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1266\" height=\"614\" src=\"https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1.png\" alt=\"\" class=\"wp-image-7479\" srcset=\"https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1.png 1266w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-300x145.png 300w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-1024x497.png 1024w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-768x372.png 768w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-500x242.png 500w\" sizes=\"auto, (max-width: 1266px) 100vw, 1266px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This is a highly translational project aiming at harnessing the tumoricidal activities of CD4+ T cells to optimize cancer immunotherapies. The project includes preclinical validation of TCR-engineered CD4 T cells and the setup of a Phase 1 clinical trial for relapsed and refractory solid tumors in both adult and childhood cohorts.<\/p>\n","protected":false},"featured_media":0,"template":"","cat-recherche":[75,93],"class_list":["post-3595","recherche","type-recherche","status-publish","hentry","cat-recherche-archive","cat-recherche-tandem-2022-2"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta name=\"description\" content=\"TCR-engineered CD4 T cell transfer for optimized cancer immunotherapy in adult and pediatric patients This is a highly translational project aiming at harnessing the tumoricidal activities of CD4+ T cells to optimize cancer immunotherapies. 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