{"id":3595,"date":"2022-10-24T11:38:00","date_gmt":"2022-10-24T09:38:00","guid":{"rendered":"https:\/\/www.isrec.ch\/recherche\/tcr-engineered-cd4-t-cell-transfer-for-optimized-cancer-immunotherapy-in-adult-and-pediatric-patients\/"},"modified":"2025-02-11T15:15:57","modified_gmt":"2025-02-11T14:15:57","slug":"tcr-engineered-cd4-t-cell-transfer-for-optimized-cancer-immunotherapy-in-adult-and-pediatric-patients","status":"publish","type":"recherche","link":"https:\/\/www.isrec.ch\/en\/research\/tcr-engineered-cd4-t-cell-transfer-for-optimized-cancer-immunotherapy-in-adult-and-pediatric-patients\/","title":{"rendered":"<strong>Pediatric leukemia<\/strong> &#8211; Prof. Camilla Jandus (UNIGE), Dr. Francesco Ceppi and Prof. George Coukos (CHUV)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">TCR-engineered CD4 T cell transfer for optimized cancer immunotherapy in adult and pediatric patients<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1266\" height=\"614\" src=\"https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1.png\" alt=\"\" class=\"wp-image-7479\" srcset=\"https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1.png 1266w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-300x145.png 300w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-1024x497.png 1024w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-768x372.png 768w, https:\/\/www.isrec.ch\/app\/uploads\/2022\/10\/Screenshot-2025-02-03-at-11.58.40-1-500x242.png 500w\" sizes=\"auto, (max-width: 1266px) 100vw, 1266px\" \/><\/figure>\n\n\n\n<p>This is a highly translational project aiming at harnessing the tumoricidal activities of CD4+ T cells to optimize cancer immunotherapies. The project includes preclinical validation of TCR-engineered CD4 T cells and the setup of a Phase 1 clinical trial for relapsed and refractory solid tumors in both adult and childhood cohorts.<\/p>\n","protected":false},"featured_media":0,"template":"","cat-recherche":[77,92,93,95],"class_list":["post-3595","recherche","type-recherche","status-publish","hentry","cat-recherche-tandem-en","cat-recherche-tandem-2022-en","cat-recherche-tandem-2022-2","cat-recherche-tandem-2022-en-2"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche\/3595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche"}],"about":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/types\/recherche"}],"wp:attachment":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/media?parent=3595"}],"wp:term":[{"taxonomy":"cat-recherche","embeddable":true,"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/cat-recherche?post=3595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}