{"id":6633,"date":"2024-07-01T16:30:41","date_gmt":"2024-07-01T14:30:41","guid":{"rendered":"https:\/\/www.isrec.ch\/?post_type=recherche&#038;p=6633"},"modified":"2025-08-22T13:28:36","modified_gmt":"2025-08-22T11:28:36","slug":"unravelling-the-rules-for-t-cell-recognition-of-cancer-epitopes-prof-david-gfeller","status":"publish","type":"recherche","link":"https:\/\/www.isrec.ch\/en\/research\/unravelling-the-rules-for-t-cell-recognition-of-cancer-epitopes-prof-david-gfeller\/","title":{"rendered":"<strong>Mechanisms of recognition of cancer cells by the immune system<\/strong>\u00a0&#8211; Prof. David Gfeller (UNIL)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Unravelling the rules by which T cells recognize cancer-specific epitopes<\/h2>\n\n\n<div class=\"intro-text\">\n<h5>This \u201callocated fund\u201d was granted to\u00a0Prof. David Gfeller\u00a0in\u00a0July\u00a02024 for one year.<\/h5>\n<\/div>\n\n\n<p>T cells play a crucial role in cancer immunotherapy by targeting and attacking cancer cells. They do so by recognizing specific molecules, called epitopes, displayed on cancer cells&nbsp;but&nbsp;not on normal cells. To maximize the chances of detecting the wide variety of epitopes found across cancer patients, different T cells are endowed with different receptors. T&nbsp;cell receptors recognizing cancer epitopes are promising for therapeutic applications, since T cells can be engineered to express these receptors and infused into patients.<\/p>\n\n\n\n<p>Today, it is&nbsp;increasingly&nbsp;possible to identify the various T&nbsp;cell receptors and the epitopes present in a tumor. However, figuring out which T cell recognizes which epitope is still very challenging.&nbsp;<\/p>\n\n\n\n<p>In our project, we will combine experimental and computational methods to characterize the recognition of cancer epitopes by T&nbsp;cell receptors. We then aim to develop AI models that can analyze large collections of T&nbsp;cell receptors from patients,&nbsp;in order&nbsp;to&nbsp;identify the most promising ones for clinical use. These results will complement ongoing research at the Department of Oncology and&nbsp;elsewhere, and&nbsp;help accelerate and streamline current pipelines to prioritize T&nbsp;cell receptor selection for T&nbsp;cell-based therapy.<\/p>\n","protected":false},"featured_media":0,"template":"","cat-recherche":[75],"class_list":["post-6633","recherche","type-recherche","status-publish","hentry","cat-recherche-archive"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche\/6633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche"}],"about":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/types\/recherche"}],"wp:attachment":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/media?parent=6633"}],"wp:term":[{"taxonomy":"cat-recherche","embeddable":true,"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/cat-recherche?post=6633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}