{"id":8257,"date":"2025-08-22T08:47:14","date_gmt":"2025-08-22T06:47:14","guid":{"rendered":"https:\/\/www.isrec.ch\/?post_type=recherche&#038;p=8257"},"modified":"2025-11-03T16:55:00","modified_gmt":"2025-11-03T15:55:00","slug":"does-tissue-fibrosis-trigger-brain-cancer-recurrence-prof-johanna-joyce-unil-and-dr-giulia-cossu-chuv","status":"publish","type":"recherche","link":"https:\/\/www.isrec.ch\/en\/research\/does-tissue-fibrosis-trigger-brain-cancer-recurrence-prof-johanna-joyce-unil-and-dr-giulia-cossu-chuv\/","title":{"rendered":"<strong>Glioblastoma<\/strong> &#8211; Prof. Johanna Joyce (UNIL) and Dr. Giulia Cossu (CHUV)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Does tissue fibrosis trigger brain cancer recurrence?<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\"><em>Spatial Analysis and Functional Interrogation of Fibrotic Scarring Niches in Glioblastoma Recurrence<\/em><\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1326\" height=\"918\" src=\"https:\/\/www.isrec.ch\/app\/uploads\/2025\/08\/mit-1.png\" alt=\"\" class=\"wp-image-8378\" srcset=\"https:\/\/www.isrec.ch\/app\/uploads\/2025\/08\/mit-1.png 1326w, https:\/\/www.isrec.ch\/app\/uploads\/2025\/08\/mit-1-300x208.png 300w, https:\/\/www.isrec.ch\/app\/uploads\/2025\/08\/mit-1-1024x709.png 1024w, https:\/\/www.isrec.ch\/app\/uploads\/2025\/08\/mit-1-768x532.png 768w, https:\/\/www.isrec.ch\/app\/uploads\/2025\/08\/mit-1-433x300.png 433w\" sizes=\"auto, (max-width: 1326px) 100vw, 1326px\" \/><\/figure>\n\n\n\n<p>Zones of fibrotic scarring are associated with tumor relapse in aggressive brain tumors. This study will use cutting-edge spatial multi-omics technologies and digital pathology analyses to explore the mechanisms that generate fibrosis in glioblastoma patients. Ultimately, the scientists hope to uncover novel therapeutic targets that disrupt the tumor-protective fibrotic niche and thereby prevent disease recurrence.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Glioblastome - Projet TANDEM 2025\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/v6zP2Us2MBo?list=PLoenJlsXpAeOR8xvFTSiJBNzVPDwiesLb\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n","protected":false},"featured_media":0,"template":"","cat-recherche":[110],"class_list":["post-8257","recherche","type-recherche","status-publish","hentry","cat-recherche-tandem-2025-en"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche\/8257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche"}],"about":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/types\/recherche"}],"wp:attachment":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/media?parent=8257"}],"wp:term":[{"taxonomy":"cat-recherche","embeddable":true,"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/cat-recherche?post=8257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}