{"id":8896,"date":"2026-05-07T18:06:32","date_gmt":"2026-05-07T16:06:32","guid":{"rendered":"https:\/\/www.isrec.ch\/?post_type=recherche&#038;p=8896"},"modified":"2026-05-29T10:28:39","modified_gmt":"2026-05-29T08:28:39","slug":"ovarian-cancer-prof-denarda-dangaj-unil","status":"publish","type":"recherche","link":"https:\/\/www.isrec.ch\/en\/research\/ovarian-cancer-prof-denarda-dangaj-unil\/","title":{"rendered":"<strong>Ovarian Cancer<\/strong>\u00a0\u2013 Prof.\u00a0Denarda\u00a0Dangaj\u00a0(UNIL)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Improving the&nbsp;Use&nbsp;of the Ovarian Cancer Immune Landscape&nbsp;for&nbsp;Precision Therapies<br><\/h2>\n\n\n<h5 style=\"text-align: left;\">Prof. Denarda Dangaj was granted this \u201callocated fund\u201d in August 2026 for 3 years.<\/h5>\n\n<div class=\"wp-bootstrap-blocks-row row\">\n\t\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<p>Ovarian cancer remains a leading cause of cancer-related death among women.&nbsp;It poses a particular challenge,&nbsp;as relapses after standard treatments are a frequent occurrence and&nbsp;thedisease still responds poorly to immunotherapy.&nbsp;The present project aims to&nbsp;improve our understanding of&nbsp;why certain tumors recur after chemotherapy and how they manage to evade the immune system. The objective is to pave the way for more&nbsp;specific&nbsp;and personalized therapeutic strategies. &nbsp;<\/p>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"283\" height=\"289\" src=\"https:\/\/www.isrec.ch\/app\/uploads\/2026\/05\/image005-1.png\" alt=\"\" class=\"wp-image-8897\"\/><\/figure>\n\n\t<\/div>\n\n<\/div>\n\n\n\n<p>To answer these questions, the scientists are analyzing tumor samples from 69 patients,&nbsp;andcomparing initial tumors with those that appeared after treatment.&nbsp;Using advanced technics, including digital pathology and single-cell sequencing, they are performing a detailed study of the organization and role of immune cells within the tumor microenvironment. A particular focus is placed on T lymphocytes and myeloid cells such as macrophages and dendritic cells.&nbsp;Preclinical mouse models complement this approach&nbsp;by&nbsp;allowing&nbsp;the researchers&nbsp;to&nbsp;monitordisease&nbsp;progression&nbsp;under conditions similar to those observed in humans.&nbsp;<\/p>\n\n\n\n<p>The project has&nbsp;enabled the identification of&nbsp;four distinct immune response profiles within ovarian tumors.&nbsp;It appears that some&nbsp;inhibit tumor progression, while others promote it.&nbsp;The research team&nbsp;aims to clarify&nbsp;the role of these different immune profiles&nbsp;and&nbsp;to identify reliable biomarkers. These&nbsp;can be used to predict disease&nbsp;progression&nbsp;and treatment response,&nbsp;to&nbsp;identify patients&nbsp;who&nbsp;can benefit from immunotherapy, and&nbsp;to&nbsp;define novel therapeutic targets to reduce the risk of relapse.&nbsp;Ultimately, this work could contribute to the development of treatments that are better adapted to patients\u2019&nbsp;individual&nbsp;immune profiles.&nbsp;<\/p>\n","protected":false},"featured_media":0,"template":"","cat-recherche":[83],"class_list":["post-8896","recherche","type-recherche","status-publish","hentry","cat-recherche-translational-research"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche\/8896","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche"}],"about":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/types\/recherche"}],"wp:attachment":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/media?parent=8896"}],"wp:term":[{"taxonomy":"cat-recherche","embeddable":true,"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/cat-recherche?post=8896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}