{"id":8896,"date":"2026-05-07T18:06:32","date_gmt":"2026-05-07T16:06:32","guid":{"rendered":"https:\/\/www.isrec.ch\/?post_type=recherche&#038;p=8896"},"modified":"2026-05-07T18:12:01","modified_gmt":"2026-05-07T16:12:01","slug":"ovarian-cancer-prof-denarda-dangaj-unil","status":"publish","type":"recherche","link":"https:\/\/www.isrec.ch\/en\/research\/ovarian-cancer-prof-denarda-dangaj-unil\/","title":{"rendered":"<strong>Ovarian Cancer<\/strong>\u00a0\u2013 Prof.\u00a0Denarda\u00a0Dangaj\u00a0(UNIL)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Improving the\u00a0Use\u00a0of the Ovarian Cancer Immune Landscape\u00a0for\u00a0Precision Therapies<br><\/h2>\n\n\n<h5>Prof. Denarda Dangaj was granted this \u201callocated fund\u201d in May 2026 for 3 years.<\/h5>\n\n<div class=\"wp-bootstrap-blocks-row row\">\n\t\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<p>Ovarian cancer remains a leading cause of cancer-related death among women.\u00a0It poses a particular challenge,\u00a0as relapses after standard treatments are a frequent occurrence and\u00a0thedisease still responds poorly to immunotherapy.\u00a0The present project aims to\u00a0improve our understanding of\u00a0why certain tumors recur after chemotherapy and how they manage to evade the immune system. The objective is to pave the way for more\u00a0specific\u00a0and personalized therapeutic strategies. \u00a0<\/p>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"283\" height=\"289\" src=\"https:\/\/www.isrec.ch\/app\/uploads\/2026\/05\/image005-1.png\" alt=\"\" class=\"wp-image-8897\"\/><\/figure>\n\n\t<\/div>\n\n<\/div>\n\n\n\n<p>To answer these questions, the scientists are analyzing tumor samples from 69 patients,&nbsp;andcomparing initial tumors with those that appeared after treatment.&nbsp;Using advanced technics, including digital pathology and single-cell sequencing, they are performing a detailed study of the organization and role of immune cells within the tumor microenvironment. A particular focus is placed on T lymphocytes and myeloid cells such as macrophages and dendritic cells.&nbsp;Preclinical mouse models complement this approach&nbsp;by&nbsp;allowing&nbsp;the researchers&nbsp;to&nbsp;monitordisease&nbsp;progression&nbsp;under conditions similar to those observed in humans.&nbsp;<\/p>\n\n\n\n<p>The project has&nbsp;enabled the identification of&nbsp;four distinct immune response profiles within ovarian tumors.&nbsp;It appears that some&nbsp;inhibit tumor progression, while others promote it.&nbsp;The research team&nbsp;aims to clarify&nbsp;the role of these different immune profiles&nbsp;and&nbsp;to identify reliable biomarkers. These&nbsp;can be used to predict disease&nbsp;progression&nbsp;and treatment response,&nbsp;to&nbsp;identify patients&nbsp;who&nbsp;can benefit from immunotherapy, and&nbsp;to&nbsp;define novel therapeutic targets to reduce the risk of relapse.&nbsp;Ultimately, this work could contribute to the development of treatments that are better adapted to patients\u2019&nbsp;individual&nbsp;immune profiles.&nbsp;<\/p>\n","protected":false},"featured_media":0,"template":"","cat-recherche":[83],"class_list":["post-8896","recherche","type-recherche","status-publish","hentry","cat-recherche-translational-research"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche\/8896","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/recherche"}],"about":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/types\/recherche"}],"wp:attachment":[{"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/media?parent=8896"}],"wp:term":[{"taxonomy":"cat-recherche","embeddable":true,"href":"https:\/\/www.isrec.ch\/en\/wp-json\/wp\/v2\/cat-recherche?post=8896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}