Does tissue fibrosis trigger brain cancer recurrence? – Prof. Johanna Joyce (UNIL) and Dr. Giulia Cossu (CHUV)

Spatial Analysis and Functional Interrogation of Fibrotic Scarring Niches in Glioblastoma Recurrence

Zones of fibrotic scarring are associated with tumor relapse in aggressive brain tumors. This study will use cutting-edge spatial multi-omics technologies and digital pathology analyses to explore the mechanisms that generate fibrosis in glioblastoma patients. Ultimately, the scientists hope to uncover novel therapeutic targets that disrupt the tumor-protective fibrotic niche and thereby prevent disease recurrence.