What bone marrow imaging can tell us about leukemia – Prof. Olaia Naveiras (CHUV/UNIL), Prof. Laurence de Leval (CHUV/UNIL), Prof. Bart Deplancke (EPFL) and Dr. Daniel Sage (EPFL)

Deepmarrow: Investigating Marrow Remodeling upon Intensive Chemotherapy as a Predictor of Response in Acute Myeloid Leukemia

In acute myeloid leukemia (AML), changes in the zone surrounding the tumor, called the stroma, can convert zones of rapid blood cell production into sites of pathological cell growth, and further lead to overt leukemia.  The goal of this study is to develop digital machine learning tools based on blood cell pathology, in order to quantify components of the connective tissue in bone marrow. This tool may also help identify AML patients with a high risk of relapsing. Such a tool should help predict and prevent relapse in AML—a clearly unmet clinical need.